Current Issue : January - March Volume : 2017 Issue Number : 1 Articles : 5 Articles
The aim of the present work was to develop formulation of nifedipine in the form of bilayer floating sustained release tablet. Bilayer tablet consist of a two layers, immediate release layer and second sustained release layer, compressed in single unit dosage form. Immediate release layer contains surface solid dispersion of nifedipine and floating sustained release layer also contain surface solid dispersion of nifedipine by using HPMC K100M and HPMC K15M as sustained release polymer. Nifedipine is an antihypertensive drug. Surface solid dispersion of nifedipine was prepared by solvent evaporation method with different super disintegrant as a polymer for improvement of solubility resulting in improved bioavailability. In the present study nifedipine bilayer floating controlled release tablets were prepared with the help of direct compression method, using sodium bicarbonate and citric acid which generate gas upon contact with gastric fluid. Immediate release layer releases the drug immediately and floating sustained release layer floats on gastric fluid for upto 12 hours and releases the drug in sustained manner, subsequently it prolongs duration of action. The tablets were evaluated for various physical parameters, buoyancy studies, dissolution studies and drug released mechanisms. The batch number F5 formulation showed minimum disintegration time of immediate release layer (24 sec) and gave maximum swelling index of the sustained release layer (82.8%) and also maximum drug release duration of nifedipine spread over 12 hours....
The purpose of the present investigation was to formulate gastroretentive floating tablets of venlafaxine\nhydrochloride thus increasing its gastric residence time and therapeutic efficacy. Venlafaxine hydrochloride having a short\nbiological half-life of 4 hrs eliminated quickly from the body leading to low therapeutic efficacy. Therefore a controlled release\nmedication was advantageous so as to achieve the prolonged therapeutic effect. This can be circumvented by formulating\nmodified gastro retentive controlled release dosage forms which resides in the stomach for sufficient time to release the drug.\nVenlafaxine hydrochloride tablets were formulated by direct compression method using polymer HPMC K4M in various\nconcentrations. Sodium bicarbonate and tartaric acid was used as effervescent producing agent. The prepared tablets were\nevaluated for pre and post compression parameters. In-vitro dissolution study was carried out in pH 1.2 buffers. It had been\nfound that increase in polymer concentration diminishes drug release profile. Among the six formulations F5 was best and\nshows 99.18% drug release in the end of 12 hrs....
Pulsatile drug delivery system delivers drug according to circadian behaviour of diseases. This means that these\nsystem deliver drug at time when diseases display it�s most morbid and mortal state within circadian cycle. The objective was to\ndesign and evaluate modified pulsincap of perindopril tert-butylamine according to circadian rhythm using formaldehyde\nvapour for cross-linking to make capsule body water insoluble and hydro gel plug to achieve a predetermined lag time for\nhypertension. The capsule body was made water insoluble by exposing the body to formaldehyde vapour. A physical mixture of\ndrug and excipients was filled in the treated capsule body and hydro gel plug was fitted to the mouth of the treated body and the\nuntreated cap was fitted to the treated body to prevent variable gastric emptying. Developed formulation was evaluated for invitro\ndrug release in pH 1.2 (2 hrs), phosphate buffer pH 6.8 (3 hrs) and phosphate buffer pH 7.4. Formulation F1 showed\npredetermined lag time of 8 hrs. Crosspovidone was used so it was selected as optimized formulation showing the immediate\nrelease of the drug after the lag time of about 8 hrs....
Gastro-retention is essential for drugs that are absorbed from the stomach, drugs that are poorly soluble or degraded\nby the higher pH of intestine and drugs with an absorption which can be modified by changes in gastric emptying time. Floating\ndrug delivery systems are those systems having a bulk density less than that of the gastric fluids and remain buoyant for a\nprolonged period of time in the stomach without being affected by the gastric emptying rate. This work is concerned with the\nformulation and in-vitro evaluation of floating tablets of an antidiabetic drug. Vildagliptin is an oral anti-hyperglycemic agent\n(anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. The objective of this study was to\nimprove the bioavailability of the drug with reduction in dosing frequency and side effects. The tablets were prepared by using\nwet granulation method. Nine formulations were developed with different polymers like xanthan gum, poly ethyleneoxide and\nHPMC K15M. FTIR studies showed no evidence on interaction with drug, polymers and excipients. The prepared tablets were\nevaluated in terms of their precompression parameters, physical characteristics, in-vitro release, buoyancy lag-time and swelling\nindex. The in-vitro drug release profiles showed that formulation (F9) exhibited 99.97% drug release at the end of 24 hours. The\nin-vitro release kinetics reveals that the formulation (F9) follows zero order and the mechanism of drug release was non-fickian....
The study was to develop a transdermal therapeutic system for ketorolac tromethamine (KT) using various polymers like ethyl cellulose (EC), hydroxy propyl methyl cellulose (HPMC) and permeation enhancers like sodium glycocholate and propylene glycol. The films were prepared by using solvent casting method and prepared films were evaluated for physicochemical properties, in-vitro drug release, ex-vivo skin permeation studies and in-vivo studies. The in-vitro release studies revealed that the release was sustained upto 24 hr and it follows zero order kinetics. Finally, the best formulation (F3) selected through in-vitro study and subjected to ex-vivo skin permeation using rat skin and in-vivo studies in rabbits. The film was also subjected to skin irritation and anti-inflammatory activity and found that there was no skin irritation and edema levels were lowered in the albino rats. As a patient friendly the transdermal film containing ketorolac tromethamine could be promising in the pasture of controlled drug delivery....
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